★★★★★4.8·Trusted for over 40+ years

VitalFactors®

VitalFactors box with effervescent tablet dissolving in glass
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Inside the formula

Four actives doing the heavy lifting.

The hero ingredients in VitalFactors — built to support cellular energy, recovery, and healthy aging in a single morning glass.

Cellular energy

NAD⁺

Nicotinamide Riboside Chloride (Super NAD+) — a clinically studied precursor that supports your cellular NAD⁺ levels.

Natural HGH support

Aminopeptide blend

L-Arginine, Glycine, L-Glutamine and L-Ornithine — amino acids studied as natural HGH secretagogues.

Antioxidant defense

Superoxide Dismutase

Extramel® SOD — a patented melon-derived enzyme that supports your body’s defense against oxidative stress.

Longevity polyphenol

Resveratrol

resVida® — clinically studied red-grape polyphenol associated with healthy-aging pathways.

The Approach

Two pathways. One daily formula.

NAD+ is a coenzyme involved in cellular energy production and DNA repair. Research suggests NAD+ levels decline with age (Imai et al., Nature Reviews 2014).

A balanced amino-acid profile and clinical-grade vitamin and mineral panel provide the cofactors involved in normal cellular metabolism, recovery, and healthy aging.

Pathway 1 — Cellular Energy

Nicotinamide Riboside Chloride, Niacinamide, and CoQ10 are nutrients involved in NAD+biology and mitochondrial function.

Pathway 2 — Healthy Aging

A clinically formulated blend of amino acids — L-Arginine, Glycine, L-Glutamine, and L-Ornithine — alongside antioxidants supports daily nutrition for healthy aging.

How it works

Daily nutrition designed for the way the body actually works.

VitalFactors is a daily formula that combines NAD+-related cofactors, antioxidants, amino acids, and a full vitamin and mineral panel into two effervescent tablets — built to give any healthy adult a complete nutritional foundation in a single glass of water.

  • Supports cellular energy and NAD⁺ biology
  • Provides amino acids and cofactors involved in recovery
  • Supports sleep quality and next-day vitality
  • Supports mental clarity and focus
  • Antioxidant defense against oxidative stress
  • Supports healthy aging of skin, hair, and connective tissue
  1. 1

    5 days on, 2 days off

    Drop two effervescent tablets in 8–12 oz of water in the morning. Stay on the 5-on / 2-off rhythm.

  2. 2

    Body absorbs

    The effervescent format dissolves the actives in water before you drink — designed for efficient absorption.

  3. 3

    Daily nutrition

    An advanced vitamin, mineral, amino-acid, and antioxidant blend supplies nutritional support for peak performance and vibrant health.

What you get

Four ways VitalFactors supports your day.

Cellular energy

Nicotinamide Riboside Chloride and CoQ10 support NAD+ biology and mitochondrial function — the foundation of how your cells make energy.

Mental clarity

Aminopeptide blend with L-Arginine, Glycine, and L-Glutamine, alongside a full vitamin and mineral panel — daily nutritional support for focus and mental performance.

Recovery & defense

resVida® Resveratrol, Extramel® SOD, EGCG, and CoQ10 — research-backed antioxidants that protect cells against oxidative aging.

Healthy aging

A clinically formulated stack supporting multiple pathways at once — cellular energy through NAD+ biology, repair and immune support via AminoPeptides and enhanced HGH, and antioxidant defenses for youthful skin, lustrous hair, and overall vitality.

Recommended By

Doctors, journalists, and athletes who take it themselves.

Chris Cuomo
Chris Cuomo
TV journalist · NewsNation primetime anchor
Fitness and nutrition unite for a vibrant, healthy lifestyle. That's why I take VitalFactors as my favorite natural energizer.
Dr. Lisa Learn
Dr. Lisa Learn
Board Certified Plastic & Reconstructive Surgeon
I take VitalFactors and give it to my patients. The only 'complaint' is that it makes our hair grow so fast, we need to visit the salon more.
Pat Boone
Pat Boone
Singer & film star, age 90 · 20+ year user
VitalFactors is my fountain of youth — I have been taking it for over 20 years.

Customer Reviews

What customers say.

4.8/ 5
★★★★★

Popular topics

EnergySleepRecoveryFocusHairSkinImmuneValue
★★★★★VerifiedVerified customer

My fountain of youth

I have been taking VitalFactors and other MDR vitamins for over 20 years. When you think I topped the charts before Elvis and I am still active and strong at 90, you can see why I call VitalFactors my 'Fountain of Youth.'

Pat Boone·Singer · Film star · Age 90
★★★★★VerifiedVerified customer

I give it to my patients

I take VitalFactors and give it to my patients. The only 'complaint' is that it makes our hair grow so fast, we need to visit the salon more.

Dr. Lisa Learn·Board Certified Plastic & Reconstructive Surgeon
★★★★★VerifiedNovember 2025

I was dragging thru the day and even felt like nodding off while driving. That was it. I tried Vital Factors because my friend said it gave her back her natural youthful energy. Within the first two days of me taking the drink, I was no longer getting tired. I felt more alert and had more focus to get more done. I also found I slept better. So grateful I found you. I will tell all my friends that aging doesn’t have to slow us down. Try MDR Vital Factors!

Chris
★★★★★VerifiedJune 2024

Been taking VitalFactors for two months. Love the taste so much that it has become my favorite drink. Hate that I’m supposed to skip 2 days a week but I follow the regimen and am feeling amazing.

Kara K.
★★★★★VerifiedOctober 2023

I was getting tired and needing to nap in the afternoon. I was putting off projects because I did not have the energy to tackle them. Now just one month after taking Vital Factors, I am my old me again…or i should say the YOUNGER ME again. I have more energy, mental sharpness, and don’t get tired but I fall asleep better at night. I am back to bicycling and swimming and feel healthier. Thanks for making this formula.

Tim

FAQ

Frequently asked.

Individual results vary. Many customers report feeling a difference in energy and focus within the first few weeks of consistent use on the 5-on / 2-off rhythm. Because VitalFactors works through nutritional support rather than a stimulant effect, most benefits build gradually with regular use.

Warnings & precautions

Caution: Do not take this product if you have kidney, liver, or gastrointestinal disease, or cancer. Consult your physician first if you are on a sodium- or potassium-restricted diet.

Allergy: Contains soy isoflavones. Free of gluten and artificial dyes. Review the full Supplement Facts panel before use.

Pregnancy & nursing: Not intended for pregnant or nursing individuals. Consult a health-care practitioner before using.

Drug interactions: If you take prescription medications — particularly blood thinners, diabetes medications, or hormone therapies — consult your physician before starting VitalFactors. Many customers paste their medication list and our Supplement Facts panel into ChatGPT to surface possible interactions worth raising with their doctor.

Storage: Cool, dry place, away from direct sunlight or moisture. Do not refrigerate. Keep out of reach of children or pets.

Caffeine: Contains none.

VitalFactors®

A Medical Doctors' Research formula. Since 1984.

© 2026 Medical Doctors' Research, Inc. All rights reserved.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary.