VitalFactors box with effervescent tablet dissolving in glass
★★★★★4.8·Read reviews

VitalFactors®

Doctor-designed effervescent formulated to support daily energy, mental clarity, and healthy aging — for any healthy adult.*

cGMP Compliant40 Years of ResearchNo Caffeine

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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary.

The Approach

Two pathways. One daily formula.

NAD+ is a coenzyme involved in cellular energy production and DNA repair. Research suggests NAD+ levels decline with age (Imai et al., Nature Reviews 2014).*

A balanced amino-acid profile and clinical-grade vitamin and mineral panel provide the cofactors involved in normal cellular metabolism, recovery, and healthy aging.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Pathway 1 — Cellular Energy

Nicotinamide Riboside Chloride, Niacinamide, and CoQ10 are nutrients involved in NAD+biology and mitochondrial function.*

Pathway 2 — Healthy Aging

A clinically formulated blend of amino acids — L-Arginine, Glycine, L-Glutamine, and L-Ornithine — alongside antioxidants supports daily nutrition for healthy aging.*

How it works

Daily nutrition designed for the way the body actually works.

VitalFactors is a daily formula that combines NAD+-related cofactors, antioxidants, amino acids, and a full vitamin and mineral panel into two effervescent tablets — built to give any healthy adult a complete nutritional foundation in a single glass of water.*

  • Supports cellular energy and NAD⁺ biology*
  • Provides amino acids and cofactors involved in recovery*
  • Supports sleep quality and next-day vitality*
  • Supports mental clarity and focus*
  • Antioxidant defense against oxidative stress*
  • Supports healthy aging of skin, hair, and connective tissue*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

  1. 1

    5 days on, 2 days off

    Drop two effervescent tablets in 8–12 oz of water in the morning. Stay on the 5-on / 2-off rhythm.

  2. 2

    Body absorbs

    The effervescent format dissolves the actives in water before you drink — designed for efficient absorption.

  3. 3

    Daily nutrition

    A complete vitamin, mineral, amino-acid, and antioxidant blend — daily nutritional support for any healthy adult.*

Compare

VitalFactors vs. typical NAD⁺ supplements.

FeatureVitalFactorsTypical NAD⁺ supplement
NAD⁺ precursorNicotinamide Riboside Chloride (Super NAD+)Often NMN or none
Amino-acid blend (Arginine, Glycine, Glutamine, Ornithine)
Antioxidant defense (Resveratrol, SOD, OPCs)
Foundational vitamin & mineral panel
Doctor-formulated since 1984
Effervescent — absorbs in solution
Monthly cost (subscribe)$89/mo$60–$120/mo

What you get

Four ways VitalFactors supports your day.

Cellular energy

Nicotinamide Riboside Chloride and CoQ10 support NAD+ biology and mitochondrial function — the foundation of how your cells make energy.*

Mental clarity

Aminopeptide blend with L-Arginine, Glycine, and L-Glutamine, alongside a full vitamin and mineral panel — daily nutritional support for focus and mental performance.*

Recovery & defense

Resveratrol, Extramel® SOD, EGCG, and N-Acetyl L-Cysteine — research-backed antioxidants that support recovery from daily oxidative stress.*

Healthy aging

A clinically formulated stack supporting two pathways at once — cellular energy through NAD+ biology, plus antioxidant defense for skin, hair, and connective tissue.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Recommended By

Doctors, journalists, and athletes who take it themselves.

Fitness and nutrition unite for a vibrant, healthy lifestyle. That's why I take VitalFactors as my favorite natural energizer.
Chris Cuomo
Chris Cuomo
TV journalist · NewsNation primetime anchor
I take VitalFactors and give it to my patients. The only 'complaint' is that it makes our hair grow so fast, we need to visit the salon more.
Dr. Lisa Learn
Dr. Lisa Learn
Board Certified Plastic & Reconstructive Surgeon
VitalFactors is my fountain of youth — I have been taking it for over 20 years.
Pat Boone
Pat Boone
Singer & film star, age 90 · 20+ year user

Customer Reviews

What customers say.

4.8/ 5
★★★★★

From 32 customer reviews

Popular topics

EnergySleepRecoveryFocusHairSkinImmuneValue
★★★★★VerifiedVerified customer

My fountain of youth

"I have been taking VitalFactors and other MDR vitamins for over 20 years. When you think I topped the charts before Elvis and I am still active and strong at 90, you can see why I call VitalFactors my 'Fountain of Youth.'"

Pat Boone·Singer · Film star · Age 90
★★★★★VerifiedVerified customer

I give it to my patients

"I take VitalFactors and give it to my patients. The only 'complaint' is that it makes our hair grow so fast, we need to visit the salon more."

Dr. Lisa Learn·Board Certified Plastic & Reconstructive Surgeon
★★★★★VerifiedNovember 2025

"I was dragging thru the day and even felt like nodding off while driving. That was it. I tried Vital Factors because my friend said it gave her back her natural youthful energy. Within the first two days of me taking the drink, I was no longer getting tired. I felt more alert and had more focus to get more done. I also found I slept better. So grateful I found you. I will tell all my friends that aging doesn’t have to slow us down. Try MDR Vital Factors!"

Chris
★★★★VerifiedMay 2025

"They work well, but I prefer the original formula. The original had a purple color, packed more of an energy kick, and tasted better. The original formula was a 5 - star product."

Aaron Holt
★★★★★VerifiedJune 2024

"Been taking VitalFactors for two months. Love the taste so much that it has become my favorite drink. Hate that I’m supposed to skip 2 days a week but I follow the regimen and am feeling amazing."

Kara Kindar

Customer reviews shown above are sourced from verified mdr.com purchases. Individual results vary — your purchase does not guarantee the same outcome.

FAQ

Frequently asked.

Individual results vary. Many customers report feeling a difference in energy and focus within the first few weeks of consistent use on the 5-on / 2-off rhythm. Because VitalFactors works through nutritional support rather than a stimulant effect, most benefits build gradually with regular use.*

Important information

Warnings & precautions.

Caution — Conditions & restricted diets

Do not take this product if you have kidney, liver, or gastrointestinal disease, or cancer. Consult your physician first if you are on a sodium- or potassium-restricted diet.

Allergy & sensitivity

VitalFactors contains soy isoflavones (sourced from soy). Free of gluten and artificial dyes. Not for individuals with a history of hypersensitivity to any ingredient — review the full Supplement Facts panel before use.

Pregnancy & nursing

Not intended for individuals who are pregnant or nursing. Consult a health-care practitioner before using.

Drug interactions

If you take prescription medications — particularly blood thinners, diabetes medications, or hormone therapies — consult your physician before starting VitalFactors.

Helpful tip: many customers paste their current medication list together with our Supplement Facts panel into ChatGPT to surface possible interactions worth discussing with their physician. It's not medical advice — just a useful starting point for that conversation.

Storage

Store in a cool, dry place away from direct sunlight or moisture. Do not store in the refrigerator. Keep out of reach of children or pets.

Caffeine

Contains no caffeine. Will not cause jitters or stimulant-type spikes.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary.