“I take VitalFactors and recommend it to my patients: an easy part of a healthy routine.”
Dr. Lisa LearnBoard Certified Plastic and Reconstructive Surgeon
Paid MDR endorser. Individual results vary.
$15 Cuomo discount applied. Code CUOMO
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- 4.9 / 5Rated by our customers
- Since 1984Made by MDR
- VitalNAD+™NMN + NADH
- Free shippingOn every subscription
“Fitness and nutrition go hand in hand. That's why I take VitalFactors as my favorite natural energizer.”
Individual results vary.
A new advance in healthy aging
VitalFactors® is a refreshing, sparkling drink with VitalNAD+™ and age-defying nutrients that support natural energy, mental clarity, muscle function, immune health and healthy aging, helping you stay sharp, active and full of vitality.*
For more than 40 years, MDR has followed the science of nutrition, updating our formulas as research advances. Now we’re introducing one of our most exciting improvements to VitalFactors®, our new VitalNAD+™ Complex, inspired by research into how certain nutritional compounds can help support youthful energy and promote healthy aging.*
Fuel trillions of tiny power plants
Inside your cells are mitochondria, your cellular power plants. They turn nutrients into energy for your brain, heart, muscles and other organs. Youthful energy is about more than simply feeling awake. Your cells need energy to function and repair, supporting the physical and mental demands of everyday life.
NAD+ plays an essential role in these processes, but research shows its levels decline with age in many tissues of the body.1 That is why we updated VitalFactors with VitalNAD+™, a blend of NADH, which helps produce the energy your brain, heart and muscles need every day, plus NMN, shown in human studies to increase NAD+ levels, supporting youthful cellular energy, DNA repair, immune function, memory and healthy aging.*
VitalFactors® helps support:
- Energy & Stamina*
- Muscle Tone*
- Immune Defenses*
- Brain Function*
- Heart Health*
- Youthful Skin*
Who’s it for? VitalFactors® is for adults who want to support their energy, protect their cells, and stay active as they age. It combines our VitalNAD+™ Complex with antioxidants in a refreshing, sparkling drink that fits easily into your morning routine to support all-day stamina and robust health.*
1. Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nature Reviews Molecular Cell Biology, 2021;22:119–141.
The Science of Youthful Vitality
An advanced nutritional approach to cellular energy, protection and renewal.
Antioxidant defense*
Resveratrol, EGCG, Grape Seed and Superoxide Dismutase help protect your cells against oxidative stress: daily wear and tear that contributes to aging.*
Stimulant-free energy support*
VitalFactors® supports your body's natural energy production without caffeine or other stimulants.*
Repair & Renew*
VitalFactors® provides key amino acids, vitamins and minerals your body needs to make proteins and support natural cell renewal, helping maintain healthy function throughout your brain and body.*
Support your muscles. Keep moving.
Maintaining muscle and strength becomes increasingly important as we age. VitalFactors® supplies our Youth Peptides, a blend of arginine, glycine and glutamine, along with vitamin D3, magnesium and potassium, which support normal muscle function.*
Keep your brain in the game
Your brain needs a tremendous amount of energy. Vitamin B12, magnesium, NMN and antioxidants support energy metabolism and healthy brain and nervous system function, essential foundations for an active mind.*
Support your immune system
Vitamin D3 and selenium help maintain healthy immune function, and the formula also includes laminaria, a brown seaweed that is a natural source of fucoidan.*
The Powerful VitalFactors® Complex
VitalFactors goes beyond ordinary vitamins. Our formula is based on the latest research with the most effective nutrients: Youth Factors, Antioxidants, Amino Peptides, BioProtectors and Enzymes. These carefully selected compounds have been shown to nourish cells and support energy, renewal, muscle function and immune defenses, key foundations for staying healthy and strong as you age.*
VitalNAD+™NMN and NADH
resVida® ResveratrolPure resVida®, with grape seed extract
EGCGGreen tea extract
Superoxide DismutaseS.O.D. from Extramel® melon
Not all resveratrol is the same. Many formulas use inexpensive resveratrol extracted from Japanese knotweed, but VitalFactors uses resVida®, a pure, highly active form made without those contaminants, and blends it with grape seed extract standardized to 95% polyphenols. VitalFactors is powered by VitalNAD+™ and the EfferNAD™ Delivery System, and it contains no sugar, artificial dyes, cholesterol, dairy, gluten, yeast or animal ingredients.
A minute in the morning.
No capsules to swallow and no measuring or stirring. A light, berry-pink sparkling drink with 24 calories, sweetened with monk fruit and stevia.
1DropDrop two tablets into a glass with about 8 ounces of water.
2FizzGive them a minute or two to fizz and dissolve completely.
3SipDrink it five days a week, then take two days off.
Fitness and nutrition, hand in hand.
VitalFactors is built for people who want to feel young and keep moving as the years add up. It supports energy and stamina the nutritional way, without a jolt of caffeine.
- NMN, a precursor your cells use to make NAD+, which is involved in normal energy metabolism
- B vitamins that support normal energy metabolism
- Resveratrol, EGCG and S.O.D. for antioxidant support
- L-glutamine, L-arginine and glycine in every serving
Three months, $15 off, a free moisturizer.
Three boxes for $214 today, plus a Free Anti-Aging Face & Neck Moisturizer. Renews at $229 every 3 months.
$229 $214 today
Pause, skip or cancel online anytime. Questions? Call 1-800-637-8227.
Real customers. Real routines.
4.9Customer rating
“I have taken VitalFactors and other MDR products religiously for over 30 years! When you think I topped the charts before Elvis, and I am still performing, feeling great at 92, you can see why I call VitalFactors my Fountain of Youth!”
“Fitness and nutrition go hand in hand. That's why I take VitalFactors as my favorite natural energizer.”
Nick Murtha, Catalyst Fitness Dr. Lisa Learn on VitalFactors (paid endorser) Dr. Lisa Learn is a paid MDR endorser. Individual results vary.
Dr. Russell Smith and Heather
My favorite drink
“Been taking VitalFactors for two months. Love the taste so much that it has become my favorite drink. Hate that I’m supposed to skip 2 days a week but I follow the regimen and am feeling amazing.”
I feel my best
“At age 76, I feel my absolute best when I take Vital Factors. It provides me the energy I need and the mental alertness to accomplish my goals on a daily basis. Also helps me accomplish my exercise goals.”
My wife takes it too
“I have been taking VitalFactors for several years now and I can say I definitely see and feel the difference! I follow the recommended usage of five days on/two days off and it is working great for me. I now have my wife on this product and highly recommend it to anyone who wants to feel (and look) their best.”
What is Vital Factors?
Vital Factors (written VitalFactors) is a fizzy drink from MDR, the nutrition company making supplements since 1984. You drop two tablets in a glass of water, five days on and two days off. Each glass has VitalNAD+™ (NMN and NADH), resveratrol, EGCG and S.O.D. to support energy and healthy aging.
Does Chris Cuomo take Vital Factors?
Yes. Chris Cuomo talks about VitalFactors on SiriusXM. In his words: “Fitness and nutrition go hand in hand. That's why I take VitalFactors as my favorite natural energizer.”
How do I get the Chris Cuomo discount?
Order on this page. Code CUOMO takes $15 off your first order and is already applied, so there is nothing to type.
How do I take VitalFactors?
Drop two tablets into a glass of water, let them dissolve, and drink. Take it five days on and two days off; most people take it Monday to Friday and skip the weekend. For the best results, take it on an empty stomach, at least 30 minutes before breakfast or 2 hours after a meal, and not right before bedtime. If you are new to VitalFactors or petite, start with half to one EfferTab and work up to two.
How many servings are in a box?
Each box has 40 EfferTabs, so the number of servings depends on how many you use: half an EfferTab gives you 80 servings, one EfferTab gives you 40 servings, and two EfferTabs, the most popular amount, give you 20 servings.
Why five days on and two days off?
VitalFactors has been designed around a weekly rhythm from the start. The cycle is what matters, not the exact days, and missing a day inside the week is fine.
How soon will I notice a difference?
Everyone is different. Many customers tell us they notice a difference within the first few weeks of taking it consistently. It is nutritional support, not a stimulant, so give it time.
Does it have caffeine or sugar?
No caffeine and no sugar. It is sweetened with monk fruit and stevia and has 24 calories per serving.
Can I cancel my subscription?
Yes. Pause, skip or cancel anytime from your MDR account. No phone call and no fees.
What if it isn't for me?
Every order is covered by our 90-day money-back guarantee. Call 1-800-637-8227 and we'll sort it out.
Does it contain allergens?
It contains soy. It does not contain dairy, gluten, yeast, eggs, fish, shellfish, tree nuts or peanuts.
Can I take it with my medications?
If you take prescription medication, especially blood thinners, diabetes medication or hormone therapy, ask your doctor or pharmacist before starting VitalFactors.
Who makes VitalFactors?
MDR, an American nutrition company that has been making supplements since 1984.
Safety informationWarnings, allergens and storage
Caution: Do not take this product if you have kidney, liver or gastrointestinal disease, or cancer. Consult your physician first if you are on a sodium- or potassium-restricted diet.
Allergy: Contains soy. Review the full Supplement Facts panel before use.
Pregnancy and nursing: Not intended for pregnant or nursing individuals. Consult a health care practitioner before using.
Medications: If you take prescription medication, especially blood thinners, diabetes medication or hormone therapy, ask your physician or pharmacist before using VitalFactors.
Storage: Keep in a cool, dry place away from direct sunlight and moisture. Do not refrigerate. Keep out of reach of children and pets.