
Feel young again.
The sparkling drink with VitalNAD+™ for natural energy and healthy aging.*
For optimum results, drink VitalFactors® 5 days a week.
Renews at $89 every 4 weeks until canceled.
100% Satisfaction Guaranteed! Hold or cancel anytime.
- Since 1984An American nutrition company
- 2 million+MDR customers
- 4.9 out of 5Customer rating
- Free shippingOn every subscription
For optimum results, drink VitalFactors® 5 days a week.
Five days on, two days off. Consistency is what makes the difference.

Are you noticing signs of aging?
- You get tired earlier in the day than you used to
- You find yourself wanting an afternoon nap
- Your muscles don’t bounce back after exercise the way they once did
- You simply feel older than your age
Most of us start to notice these changes somewhere past 40, and that is exactly the time of life VitalFactors® was made for. It is formulated for adults 35 and older who want to stay strong, stay sharp and stay active.*

A new advance in healthy aging
VitalFactors® is a refreshing, sparkling drink with VitalNAD+™ and age-defying nutrients that support natural energy, mental clarity, muscle function, immune health and healthy aging, helping you stay sharp, active and full of vitality.*
VitalFactors® helps support:
- Energy & Stamina*
- Muscle Tone*
- Immune Defenses*
- Brain Function*
- Heart Health*
- Youthful Skin*

Fuel trillions of tiny power plants
Inside your cells are mitochondria, your cellular power plants. They turn nutrients into energy for your brain, heart, muscles and other organs.
NAD+ plays an essential role, but research shows its levels decline with age in many tissues of the body.1 That is why we updated VitalFactors with VitalNAD+™: NADH, which helps produce the energy your brain, heart and muscles need, plus NMN, shown in human studies to increase NAD+ levels.*
Powered by VitalNAD+™ and the EfferNAD™ Delivery System.
1. Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nature Reviews Molecular Cell Biology, 2021;22:119–141.
The Science of Youthful Vitality
An advanced nutritional approach to cellular energy, protection and renewal.
The Powerful VitalFactors® Complex
VitalNAD+™NMN and NADH
resVida® ResveratrolWith grape seed extract
EGCGGreen tea extract
Superoxide DismutaseS.O.D. from Extramel® melon
Antioxidant defense*
Resveratrol, EGCG, Grape Seed and Superoxide Dismutase help protect your cells against oxidative stress.*
Stimulant-free energy support*
Supports your body’s natural energy production without caffeine or other stimulants.*
Repair & Renew*
Key amino acids, vitamins and minerals your body needs to support natural cell renewal.*
Support your muscles. Keep moving.
Our Youth Peptides (arginine, glycine and glutamine), with vitamin D3, magnesium and potassium, support normal muscle function.*
Keep your brain in the game
Vitamin B12, magnesium, NMN and antioxidants support healthy brain and nervous system function.*
Support your immune system
Vitamin D3 and selenium help maintain healthy immune function.*
VitalFactors goes beyond ordinary vitamins. It uses resVida®, a pure, highly active form of resveratrol, with grape seed extract standardized to 95% polyphenols, and contains no sugar, artificial dyes, cholesterol, dairy, gluten, yeast or animal ingredients.
How to take VitalFactors
For optimum results, drink VitalFactors® 5 days a week. Five days on, two days off. Consistency is what makes the difference.
1DropDrop two tablets into a glass with about 8 ounces of water.
2FizzGive them a minute or two to fizz and dissolve completely.
3SipDrink it five days a week, then take two days off.
Why Pat Boone and Chris Cuomo take VitalFactors

“I have taken VitalFactors and other MDR products religiously for over 30 years! When you think I topped the charts before Elvis, and I am still performing, feeling great at 92, you can see why I call VitalFactors my Fountain of Youth!”

“Fitness and nutrition go hand in hand. That's why I take VitalFactors as my favorite natural energizer.”
Doctors take VitalFactors
Choose your planDr. Lisa Learn on VitalFactors (paid endorser) “More energy at work, the ability to focus even that much better. And it also gave me that afternoon lift so that I could actually complete the day and then go work out after that.”
Dr. Lisa LearnPlastic surgeon, Fort Lauderdale
Dr. Lisa Learn is a paid MDR endorser. Individual results vary.
Dr. Russell Smith and Heather “VitalFactors just gives me the stamina to go through the 12-hour shifts in the emergency room, which requires a lot of mental capacity and endurance, as well as my outdoor activities.”
Dr. Russell SmithEmergency room physician, with his wife Heather
What customers say
4.9 out of 5
I feel my best
“At age 76, I feel my absolute best when I take Vital Factors. It provides me the energy I need and the mental alertness to accomplish my goals on a daily basis. Also helps me accomplish my exercise goals.”
Judith H. · VitalFactors customer
Alive and healthy
“Feeling so alive and healthy!! So grateful!!”
Barbara M. · VitalFactors customer
My wife takes it too
“I have been taking VitalFactors for several years now and I can say I definitely see and feel the difference! I follow the recommended usage of five days on/two days off and it is working great for me. I now have my wife on this product and highly recommend it to anyone who wants to feel (and look) their best.”
John R. · VitalFactors customer
Twenty years and counting
“I've been taking/drinking Vital Factors for at least 20 years and never want to stop. The benefits are amazing! Thank you for making such a great vitamin drink.”
Lynn W. · VitalFactors customer
Testimonials reflect individual experiences. Results vary.

Feel young. Live young.
Choose your plan.
100% Satisfaction Guaranteed! Hold or cancel anytime.
Free shipping on every subscription.
Questions?
MDR Customer Service is happy to help.
Call 1-800-637-8227.
How do I take VitalFactors?
Drop two tablets into a glass of water, let them dissolve, and drink. Take it five days on and two days off; most people take it Monday to Friday and skip the weekend. For the best results, take it on an empty stomach, at least 30 minutes before breakfast or 2 hours after a meal, and not right before bedtime. If you are new to VitalFactors or petite, start with half to one EfferTab and work up to two.
How soon will I notice a difference?
Everyone is different. Many customers tell us they notice a difference within the first few weeks of taking it consistently. It is nutritional support, not a stimulant, so give it time.
Does it have caffeine or sugar?
No caffeine and no sugar. It is sweetened with monk fruit and stevia and has 24 calories per serving.
Can I cancel my subscription?
Yes. Pause, skip or cancel anytime from your MDR account. No phone call and no fees.
What if it isn't for me?
Every order is covered by our 90-day money-back guarantee. Call 1-800-637-8227 and we'll sort it out.
Can I take it with my medications?
If you take prescription medication, especially blood thinners, diabetes medication or hormone therapy, ask your doctor or pharmacist before starting VitalFactors.
What is VitalNAD+™?
VitalNAD+™ is the combination of NMN and NADH in VitalFactors®, designed to support cellular energy.*
What Is VitalNAD+™?
VitalNAD+™ is the combination of NMN and NADH in VitalFactors®, designed to support cellular energy.*
What is NAD, and why does my body need it?
NAD stands for nicotinamide adenine dinucleotide, a natural coenzyme, a helper molecule found in your cells. It exists in two forms, NAD+ and NADH, which your body continually converts from one to the other to help turn food into energy. NAD+ also supports enzymes involved in DNA repair and normal cell function.*
What is NMN?
NMN stands for nicotinamide mononucleotide. It is a building block your body uses to make NAD+. Human clinical studies have shown that NMN supplementation can increase NAD+ levels in the blood.
What is NADH?
NADH is the form of NAD that carries electrons used in energy production. It plays a role in your mitochondria, the energy-producing structures inside your cells, to help make ATP, the energy your cells use to function.
Why does VitalFactors include both?
They have complementary roles: NMN helps your body make NAD+, while NADH participates in producing ATP. We include both to support this essential energy system.*
What does cellular energy mean for my everyday life?
Your body needs energy every moment of every day. The energy processes involving NAD+ and NADH help:
- Power your heart as it pumps blood throughout your body.
- Fuel your brain as it processes information, learns and remembers.
- Keep your muscles working so you can move and stay active.
Supporting cellular energy helps your body perform the essential functions that keep you strong, focused and on the go with youthful vitality and good health.*
More product questions
How many servings are in a box?
Each box has 40 EfferTabs, so the number of servings depends on how many you use: half an EfferTab gives you 80 servings, one EfferTab gives you 40 servings, and two EfferTabs, the most popular amount, give you 20 servings.
Why five days on and two days off?
VitalFactors has been designed around a weekly rhythm from the start. The cycle is what matters, not the exact days, and missing a day inside the week is fine.
Does it contain allergens?
It contains soy. It does not contain dairy, gluten, yeast, eggs, fish, shellfish, tree nuts or peanuts.
Who makes VitalFactors?
MDR, an American nutrition company that has been making supplements since 1984.
Cautions and storage
Consult your healthcare professional before taking this or any nutritional supplement if you have a medical condition or are pregnant or nursing. Do not take this product if you have kidney, liver or gastrointestinal disease, or cancer, and consult your physician first if you are on a sodium or potassium restricted diet. Contains potassium, sodium and soy. Store in a cool, dry place away from direct sunlight or moisture, do not store it in the refrigerator, and keep it out of reach of children and pets.
Supplement Facts
Supplement Facts
Serving Size: 2 Tablets · Servings Per Container: 20
- Calories24
- Total Carbohydrates0.48 g<1%†
- Sodium274 mg12%
- Vitamin A (as Retinyl Palmitate)30 mcg RAE2%
- Vitamin C (as L-Ascorbic Acid)100 mg111%
- Vitamin D3 (as Cholecalciferol)12.5 mcg (500 IU)63%
- Vitamin E (as D-Alpha-Tocopherol Acetate)10 mg67%
- Vitamin B1 (from Thiamin Hydrochloride)3 mg250%
- Vitamin B2 (as Riboflavin)3.4 mg262%
- Niacinamide24 mg150%
- Vitamin B6 (from Pyridoxine)6 mg353%
- Folic Acid (from Pteroyl-L-Monoglutamic Acid)200 mcg DFE50%
- Vitamin B12 (from Methylcobalamin)200 mcg8333%
- Biotin50 mcg167%
- Pantothenic Acid2 mg40%
- Calcium (from Calcium Carbonate)50 mg4%
- Magnesium (from Trimagnesium Dicitrate)60 mg14%
- Selenium (from Selenomethionine)20 mcg40%
- Potassium330 mg7%
- L-Glutamine*
- NMN (ß-Nicotinamide Mononucleotide)*
- Arginine (as L-Arginine Hydrochloride)*
- Lysine (as L-Lysine Hydrochloride)*
- Glycine*
- Monk Fruit Extract (Momordica Grosvenovi, Fruit)*
- Grape Skin Extract (40% Resveratrol)*
- Coenzyme Q10*
- Grape Seed Extract (Vitis Vinifera)(95% Proanthocyanidins)*
- Soy Isoflavones (contains Soy)*
- Green Tea Extract (EGCG - Epigallocatechin Gallate)*
- Laminaria Japonica Seaweed (80% Polysaccharides)*
- Resveratrol (from resVida®**)*
- Lycopene*
- Superoxide Dismutase/Catalase (from Extramel®*** Melon)*
- Ornithine (as L-Ornithine Hydrochloride)*
- Lotus Seed Extract (Nelumbo Nucifera ****)*
- NADH (Nicotinamide Adenine Dinucleotide Hydrogen)*
† Percent Daily Values are based on a 2,000 calorie diet
* Daily Value not established.
** Resvida® is a U.S. & international registered trademark of DSM (Netherlands).
*** Extramel® is a U.S. registered trademark of Bionov Corp.
**** Lotus U.S. Patent # 5,925,348
Other ingredients: Citric Acid, Sodium Bicarbonate, Potassium Bicarbonate, Red Fruit Jelly Flavor, Berry Flavor, Steviol Glycosides.
Contains: Soy.
View the printed label