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Feel young again.

Revitalize youthful vitality.

Renews monthly. Cancel online anytime. Or buy once, $109

VitalFactors box beside a glass of the sparkling drink
“I’ve been using this product for years and have never been disappointed…”Thomas S. · customer review
4.9 / 5Customer rating
Since 1984Made by Medical Doctors' Research
Free shippingOn every subscription

VitalFactors

4.9 out of 5 customer rating

A complete effervescent formula designed to support normal energy metabolism, antioxidant protection and healthy aging.

  • 300 mgNMN
  • 0 gsugar
  • 0 mgcaffeine
  • 20servings
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Get 3 boxes for $249 and a free Anti-Aging Cream. Save $18 vs monthly.

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How to use

Drop two tablets into a glass of water, let them fully dissolve, and drink. Take VitalFactors five days on and two days off. One box: 40 tablets · 20 servings · a four-week supply.

What is inside

300 mg NMN and 8 mg NADH, resVida® resveratrol, grape skin and seed extracts, EGCG from green tea and Extramel® S.O.D., plus vitamins, minerals, amino acids and CoQ10.

Shipping, returns & cancellation

Monthly and 3-Month Subscribe & Save ship free. Pause, skip or cancel a subscription online at any time. Every order is covered by a 90-day money-back guarantee.

Feel vital, every weekday.

Weekday nutritional support for normal energy metabolism, antioxidant defenses and everyday function.*

300 mg NMN for healthy-aging support

VitalNAD+ (NMN) with resveratrol, EGCG, grape polyphenols and S.O.D. helps support cellular wellness and the body's antioxidant defenses as you age.

Caffeine-free energy support

NMN and B vitamins support the normal processes your body uses to convert nutrients into energy, without caffeine or sugar.

Vitamins, minerals and amino acids for mind and muscle

A broad formula of vitamins, minerals and amino acids helps support brain function, muscle function and everyday wellbeing.

Drop. Fizz. Sip.

Two tablets. One glass. Five days a week.

  1. Two tablets into a glass of water.01

    Drop

    Two tablets into a glass of water.

  2. They dissolve completely and the water turns pink.02

    Fizz

    They dissolve completely and the water turns pink.

  3. Drink it five days a week, then take the weekend off.03

    Sip

    Drink it five days a week, then take the weekend off.

  1. Two tablets into a glass of water.

    Drop

    Two tablets into a glass of water.

  2. They dissolve completely and the water turns pink.

    Fizz

    They dissolve completely and the water turns pink.

  3. Drink it five days a week, then take the weekend off.

    Sip

    Drink it five days a week, then take the weekend off.

See exactly what’s in every glass.

We publish the complete formula, including every ingredient in the blend. No guessing and no hidden amounts.

  • VitalNAD+™

    300 mg NMN + 8 mg NADH

    NMN is a precursor your cells use to make NAD+, a coenzyme involved in normal energy metabolism.

  • Resveratrol

    resVida® + grape skin and seed

    Red grape polyphenols that help support antioxidant protection.

  • EGCG

    40 mg from green tea

    The best-known green tea catechin, a plant antioxidant.

  • S.O.D.

    Extramel® melon extract

    Superoxide dismutase from cantaloupe, an antioxidant enzyme.

Also in every serving: vitamins A, C, D3, E and a full B complex, calcium, magnesium, selenium and potassium, plus L-glutamine, L-arginine, L-lysine, glycine and CoQ10.

Your routine, delivered.

A fresh box arrives every 30 days, so your five-days-on rhythm never runs dry. Change it whenever you like, online.

  • $20 less than a single box
  • Free shipping on every delivery
  • Pause, skip or cancel online

Renews every 30 days until you cancel.

Hands lifting three boxes of VitalFactors out of a shipping box

Real customers. Real routines.

4.9Trusted for over 40 years
  • Nick Murtha, Catalyst Fitness
  • Dr. Lisa Learn on VitalFactors (paid endorser)

    Dr. Lisa Learn is a paid MDR endorser. Individual results vary.

  • Dr. Russell Smith and Heather
  • My favorite drink

    “Been taking VitalFactors for two months. Love the taste so much that it has become my favorite drink. Hate that I’m supposed to skip 2 days a week but I follow the regimen and am feeling amazing.”
    Kara K.June 2024 Customer review
  • I feel my best

    “At age 76, I feel my absolute best when I take Vital Factors. It provides me the energy I need and the mental alertness to accomplish my goals on a daily basis. Also helps me accomplish my exercise goals.”
    Judith H.December 2022 Customer review
  • My wife takes it too

    “I have been taking VitalFactors for several years now and I can say I definitely see and feel the difference! I follow the recommended usage of five days on/two days off and it is working great for me. I now have my wife on this product and highly recommend it to anyone who wants to feel (and look) their best.”
    John R.April 2022 Customer review
Pat Boone
“I wouldn't skip a week.”

Pat BooneSinger and film star, MDR customer for over 30 years

Dr. Lisa Learn
“I take VitalFactors and recommend it to my patients: an easy part of a healthy routine.”

Dr. Lisa LearnBoard Certified Plastic and Reconstructive Surgeon

Paid MDR endorser. Individual results vary.

Chris Cuomo
“Fitness and nutrition go hand in hand. That's why I take VitalFactors as my favorite natural energizer.”

Chris CuomoTV journalist, NewsNation

Questions, answered.

Need a real person? Call 1-800-637-8227.

A man smiling with a glass of VitalFactors and the box on the counter
How do I take VitalFactors?

Drop two tablets into a glass of water, let them dissolve, and drink. Take it five days on and two days off. Most people take it Monday to Friday and skip the weekend.

Why five days on and two days off?

VitalFactors has been designed around a weekly rhythm from the start. The cycle is what matters, not the exact days, and missing a day inside the week is fine.

How soon will I notice a difference?

Everyone is different. Many customers tell us they notice a difference within the first few weeks of taking it consistently. It is nutritional support, not a stimulant, so give it time.

Does it have caffeine or sugar?

No caffeine and no sugar. It is sweetened with monk fruit and stevia and has 24 calories per serving.

Can I cancel my subscription?

Yes. Pause, skip or cancel anytime from your MDR account. No phone call and no fees.

What if it isn't for me?

Every order is covered by our 90-day money-back guarantee. Call 1-800-637-8227 and we'll sort it out.

Does it contain allergens?

It contains soy. It does not contain dairy, gluten, yeast, eggs, fish, shellfish, tree nuts or peanuts.

Can I take it with my medications?

If you take prescription medication, especially blood thinners, diabetes medication or hormone therapy, ask your doctor or pharmacist before starting VitalFactors.

Who makes VitalFactors?

MDR, an American nutrition company that has been making supplements since 1984.

Two tablets away from your first glass.

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Safety informationWarnings, allergens and storage

Caution: Do not take this product if you have kidney, liver or gastrointestinal disease, or cancer. Consult your physician first if you are on a sodium- or potassium-restricted diet.

Allergy: Contains soy. Review the full Supplement Facts panel before use.

Pregnancy and nursing: Not intended for pregnant or nursing individuals. Consult a health care practitioner before using.

Medications: If you take prescription medication, especially blood thinners, diabetes medication or hormone therapy, ask your physician or pharmacist before using VitalFactors.

Storage: Keep in a cool, dry place away from direct sunlight and moisture. Do not refrigerate. Keep out of reach of children and pets.