Feel young again.
The sparkling drink with VitalNAD+™ for natural energy and healthy aging.*
Renews monthly. Cancel anytime.
- Since 1984An American nutrition company
- 2 million+MDR customers
- 4.9 out of 5Customer rating
- Free shippingOn every subscription
How to take VitalFactors
1DropDrop two tablets into a glass with about 8 ounces of water.
2FizzGive them a minute or two to fizz and dissolve completely.
3SipDrink it five days a week, then take two days off.
Why Pat Boone and Chris Cuomo take VitalFactors
“I have taken VitalFactors and other MDR products religiously for over 30 years! When you think I topped the charts before Elvis, and I am still performing, feeling great at 92, you can see why I call VitalFactors my Fountain of Youth!”
“Fitness and nutrition go hand in hand. That's why I take VitalFactors as my favorite natural energizer.”
Doctors take VitalFactors
Dr. Lisa Learn is a plastic surgeon in Fort Lauderdale who still has the energy for a workout after a long day in surgery. Dr. Russell Smith is an emergency room physician who works 12-hour shifts, and he and his wife Heather spend their free time outdoors. Here is what they told us about VitalFactors.
Dr. Lisa Learn on VitalFactors (paid endorser) Dr. Lisa Learn on VitalFactors
Dr. Lisa Learn is a paid MDR endorser. Individual results vary.
Dr. Russell Smith and Heather Dr. Russell Smith and Heather
Are you noticing signs of aging?
Maybe you get tired earlier in the day than you used to, you find yourself wanting an afternoon nap, your muscles don’t bounce back after exercise the way they once did, or you simply feel older than your age. Most of us start to notice these changes somewhere past 40, and that is exactly the time of life VitalFactors® was made for.
VitalFactors is formulated for adults 35 and older who want to stay strong, stay sharp and stay active, and get more life out of their years.*
A new advance in healthy aging
VitalFactors® is a refreshing, sparkling drink with VitalNAD+™ and age-defying nutrients that support natural energy, mental clarity, muscle function, immune health and healthy aging, helping you stay sharp, active and full of vitality.*
For more than 40 years, MDR has followed the science of nutrition, updating our formulas as research advances. Now we’re introducing one of our most exciting improvements to VitalFactors®, our new VitalNAD+™ Complex, inspired by research into how certain nutritional compounds can help support youthful energy and promote healthy aging.*
Fuel trillions of tiny power plants
Inside your cells are mitochondria, your cellular power plants. They turn nutrients into energy for your brain, heart, muscles and other organs. Youthful energy is about more than simply feeling awake. Your cells need energy to function and repair, supporting the physical and mental demands of everyday life.
NAD+ plays an essential role in these processes, but research shows its levels decline with age in many tissues of the body.1 That is why we updated VitalFactors with VitalNAD+™, a blend of NADH, which helps produce the energy your brain, heart and muscles need every day, plus NMN, shown in human studies to increase NAD+ levels, supporting youthful cellular energy, DNA repair, immune function, memory and healthy aging.*
VitalFactors® helps support:
- Energy & Stamina*
- Muscle Tone*
- Immune Defenses*
- Brain Function*
- Heart Health*
- Youthful Skin*
Who’s it for? VitalFactors® is for adults who want to support their energy, protect their cells, and stay active as they age. It combines our VitalNAD+™ Complex with antioxidants in a refreshing, sparkling drink that fits easily into your morning routine to support all-day stamina and robust health.*
1. Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nature Reviews Molecular Cell Biology, 2021;22:119–141.
What customers say
4.9 out of 5
I feel my best
“At age 76, I feel my absolute best when I take Vital Factors. It provides me the energy I need and the mental alertness to accomplish my goals on a daily basis. Also helps me accomplish my exercise goals.”
Judith H. · VitalFactors customer
Alive and healthy
“Feeling so alive and healthy!! So grateful!!”
Barbara M. · VitalFactors customer
My wife takes it too
“I have been taking VitalFactors for several years now and I can say I definitely see and feel the difference! I follow the recommended usage of five days on/two days off and it is working great for me. I now have my wife on this product and highly recommend it to anyone who wants to feel (and look) their best.”
John R. · VitalFactors customer
Twenty years and counting
“I've been taking/drinking Vital Factors for at least 20 years and never want to stop. The benefits are amazing! Thank you for making such a great vitamin drink.”
Lynn W. · VitalFactors customer
Testimonials reflect individual experiences. Results vary.
The Science of Youthful Vitality
An advanced nutritional approach to cellular energy, protection and renewal.
Antioxidant defense*
Resveratrol, EGCG, Grape Seed and Superoxide Dismutase help protect your cells against oxidative stress: daily wear and tear that contributes to aging.*
Stimulant-free energy support*
VitalFactors® supports your body's natural energy production without caffeine or other stimulants.*
Repair & Renew*
VitalFactors® provides key amino acids, vitamins and minerals your body needs to make proteins and support natural cell renewal, helping maintain healthy function throughout your brain and body.*
Support your muscles. Keep moving.
Maintaining muscle and strength becomes increasingly important as we age. VitalFactors® supplies our Youth Peptides, a blend of arginine, glycine and glutamine, along with vitamin D3, magnesium and potassium, which support normal muscle function.*
Keep your brain in the game
Your brain needs a tremendous amount of energy. Vitamin B12, magnesium, NMN and antioxidants support energy metabolism and healthy brain and nervous system function, essential foundations for an active mind.*
Support your immune system
Vitamin D3 and selenium help maintain healthy immune function, and the formula also includes laminaria, a brown seaweed that is a natural source of fucoidan.*
The Powerful VitalFactors® Complex
VitalFactors goes beyond ordinary vitamins. Our formula is based on the latest research with the most effective nutrients: Youth Factors, Antioxidants, Amino Peptides, BioProtectors and Enzymes. These carefully selected compounds have been shown to nourish cells and support energy, renewal, muscle function and immune defenses, key foundations for staying healthy and strong as you age.*
VitalNAD+™NMN and NADH
resVida® ResveratrolPure resVida®, with grape seed extract
EGCGGreen tea extract
Superoxide DismutaseS.O.D. from Extramel® melon
Not all resveratrol is the same. Many formulas use inexpensive resveratrol extracted from Japanese knotweed, but VitalFactors uses resVida®, a pure, highly active form made without those contaminants, and blends it with grape seed extract standardized to 95% polyphenols. VitalFactors is powered by VitalNAD+™ and the EfferNAD™ Delivery System, and it contains no sugar, artificial dyes, cholesterol, dairy, gluten, yeast or animal ingredients.
Over 42 years of nutrition expertise
MDR has helped millions of men and women enjoy an active, healthy life, starting decades ago with the first patented AM/PM multivitamin, antioxidant formulation listed in the Physician’s Desk Reference.
MDR stands for Medical Doctors Research. Founded in Sunrise, Florida, in 1984, our family-owned company has spent more than 40 years helping our customers maintain their health, vitality and independence as they age. Every formula serves a clear purpose: to help optimize your health and well-being so you can enjoy life to the fullest.
Questions?
MDR Customer Service is happy to help.
Call 1-800-637-8227.
How do I take VitalFactors?
Drop two tablets into a glass of water, let them dissolve, and drink. Take it five days on and two days off. Most people take it Monday to Friday and skip the weekend.
How soon will I notice a difference?
Everyone is different. Many customers tell us they notice a difference within the first few weeks of taking it consistently. It is nutritional support, not a stimulant, so give it time.
Does it have caffeine or sugar?
No caffeine and no sugar. It is sweetened with monk fruit and stevia and has 24 calories per serving.
Can I cancel my subscription?
Yes. Pause, skip or cancel anytime from your MDR account. No phone call and no fees.
What if it isn't for me?
Every order is covered by our 90-day money-back guarantee. Call 1-800-637-8227 and we'll sort it out.
Can I take it with my medications?
If you take prescription medication, especially blood thinners, diabetes medication or hormone therapy, ask your doctor or pharmacist before starting VitalFactors.
What is VitalNAD+™?
VitalNAD+™ is the combination of NMN and NADH in VitalFactors®, designed to support cellular energy.*
What Is VitalNAD+™?
VitalNAD+™ is the combination of NMN and NADH in VitalFactors®, designed to support cellular energy.*
What is NAD, and why does my body need it?
NAD stands for nicotinamide adenine dinucleotide, a natural coenzyme, a helper molecule found in your cells. It exists in two forms, NAD+ and NADH, which your body continually converts from one to the other to help turn food into energy. NAD+ also supports enzymes involved in DNA repair and normal cell function.*
What is NMN?
NMN stands for nicotinamide mononucleotide. It is a building block your body uses to make NAD+. Human clinical studies have shown that NMN supplementation can increase NAD+ levels in the blood.
What is NADH?
NADH is the form of NAD that carries electrons used in energy production. It plays a role in your mitochondria, the energy-producing structures inside your cells, to help make ATP, the energy your cells use to function.
Why does VitalFactors include both?
They have complementary roles: NMN helps your body make NAD+, while NADH participates in producing ATP. We include both to support this essential energy system.*
What does cellular energy mean for my everyday life?
Your body needs energy every moment of every day. The energy processes involving NAD+ and NADH help:
- Power your heart as it pumps blood throughout your body.
- Fuel your brain as it processes information, learns and remembers.
- Keep your muscles working so you can move and stay active.
Supporting cellular energy helps your body perform the essential functions that keep you strong, focused and on the go with youthful vitality and good health.*
More product questions
How many servings are in a box?
Each box has 40 EfferTabs, so the number of servings depends on how many you use: half an EfferTab gives you 80 servings, one EfferTab gives you 40 servings, and two EfferTabs, the most popular amount, give you 20 servings.
Why five days on and two days off?
VitalFactors has been designed around a weekly rhythm from the start. The cycle is what matters, not the exact days, and missing a day inside the week is fine.
Does it contain allergens?
It contains soy. It does not contain dairy, gluten, yeast, eggs, fish, shellfish, tree nuts or peanuts.
Who makes VitalFactors?
MDR, an American nutrition company that has been making supplements since 1984.
Cautions and storage
Consult your healthcare professional before taking this or any nutritional supplement if you have a medical condition or are pregnant or nursing. Do not take this product if you have kidney, liver or gastrointestinal disease, or cancer, and consult your physician first if you are on a sodium or potassium restricted diet. Contains potassium, sodium and soy. Store in a cool, dry place away from direct sunlight or moisture, do not store it in the refrigerator, and keep it out of reach of children and pets.
Supplement Facts
Supplement Facts
Serving Size: 2 Tablets · Servings Per Container: 20
- Calories24
- Total Carbohydrates0.48 g<1%†
- Sodium274 mg12%
- Vitamin A (as Retinyl Palmitate)30 mcg RAE2%
- Vitamin C (as L-Ascorbic Acid)100 mg111%
- Vitamin D3 (as Cholecalciferol)12.5 mcg (500 IU)63%
- Vitamin E (as D-Alpha-Tocopherol Acetate)10 mg67%
- Vitamin B1 (from Thiamin Hydrochloride)3 mg250%
- Vitamin B2 (as Riboflavin)3.4 mg262%
- Niacinamide24 mg150%
- Vitamin B6 (from Pyridoxine)6 mg353%
- Folic Acid (from Pteroyl-L-Monoglutamic Acid)200 mcg DFE50%
- Vitamin B12 (from Methylcobalamin)200 mcg8333%
- Biotin50 mcg167%
- Pantothenic Acid2 mg40%
- Calcium (from Calcium Carbonate)50 mg4%
- Magnesium (from Trimagnesium Dicitrate)60 mg14%
- Selenium (from Selenomethionine)20 mcg40%
- Potassium330 mg7%
- L-Glutamine*
- NMN (ß-Nicotinamide Mononucleotide)*
- Arginine (as L-Arginine Hydrochloride)*
- Lysine (as L-Lysine Hydrochloride)*
- Glycine*
- Monk Fruit Extract (Momordica Grosvenovi, Fruit)*
- Grape Skin Extract (40% Resveratrol)*
- Coenzyme Q10*
- Grape Seed Extract (Vitis Vinifera)(95% Proanthocyanidins)*
- Soy Isoflavones (contains Soy)*
- Green Tea Extract (EGCG - Epigallocatechin Gallate)*
- Laminaria Japonica Seaweed (80% Polysaccharides)*
- Resveratrol (from resVida®**)*
- Lycopene*
- Superoxide Dismutase/Catalase (from Extramel®*** Melon)*
- Ornithine (as L-Ornithine Hydrochloride)*
- Lotus Seed Extract (Nelumbo Nucifera ****)*
- NADH (Nicotinamide Adenine Dinucleotide Hydrogen)*
† Percent Daily Values are based on a 2,000 calorie diet
* Daily Value not established.
** Resvida® is a U.S. & international registered trademark of DSM (Netherlands).
*** Extramel® is a U.S. registered trademark of Bionov Corp.
**** Lotus U.S. Patent # 5,925,348
Other ingredients: Citric Acid, Sodium Bicarbonate, Potassium Bicarbonate, Red Fruit Jelly Flavor, Berry Flavor, Steviol Glycosides.
Contains: Soy.
View the printed labelFeel young. Live young.
When your cells have the energy they need, your body performs at its best, giving you the strength and stamina to stay active, the mental clarity to stay sharp and the vitality to keep doing the things you love.* Make your health a priority, and invite someone you love to do the same.
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