Energy without the stimulant cycle
NMN and B vitamins support the normal processes your body uses to convert nutrients into energy, without caffeine or sugar.
Caffeine-free cellular nutrition
A refreshing five-day ritual with 300 mg NMN, resveratrol, EGCG and S.O.D. No caffeine. No sugar. Nothing to swallow.


A VitalFactors tablet dissolving in a glass of water next to the box
One box. One month. One easy ritual.
A complete effervescent formula designed to support normal energy metabolism, antioxidant protection and healthy aging.
Drop two tablets into a glass of water, let them fully dissolve, and drink. Take VitalFactors five days on and two days off. One box contains 40 tablets, or 20 servings.
300 mg NMN and 8 mg NADH, resVida® resveratrol, grape skin and seed extracts, EGCG from green tea and Extramel® S.O.D., plus vitamins, minerals, amino acids and CoQ10.
Subscriptions and 3-month supplies ship free. Pause, skip or cancel a subscription online at any time. Every order is covered by a 90-day money-back guarantee.
Why it feels different
VitalFactors works with the body's normal energy and antioxidant systems. It is nutritional support, not a stimulant.
NMN and B vitamins support the normal processes your body uses to convert nutrients into energy, without caffeine or sugar.
A broad formula of vitamins, minerals and amino acids helps support brain function, muscle function and everyday wellbeing.
Resveratrol, EGCG, grape polyphenols and S.O.D. help support the body's antioxidant defenses against free radicals.
The five-minute habit
Two tablets. One glass. Five days a week.
01Two tablets into a glass of water.
02They dissolve completely and the water turns pink.
03Drink it five days a week, then take the weekend off.
Formula transparency
We publish the complete formula, including every ingredient in the blend. No guessing and no hidden amounts.

NMN is a precursor your cells use to make NAD+, a coenzyme involved in normal energy metabolism.

Red grape polyphenols that help support antioxidant protection.

The best-known green tea catechin, a plant antioxidant.

Superoxide dismutase from cantaloupe, an antioxidant enzyme.
Also in every serving: vitamins A, C, D3, E and a full B complex, calcium, magnesium, selenium and potassium, plus L-glutamine, L-arginine, L-lysine, glycine and CoQ10.

Subscribe & Save
Your next box arrives every 30 days, right when you need it. No commitment and no call required to make changes.
Real routines. Real people.
“Been taking VitalFactors for two months. Love the taste so much that it has become my favorite drink. Hate that I’m supposed to skip 2 days a week but I follow the regimen and am feeling amazing.”
“At age 76, I feel my absolute best when I take Vital Factors. It provides me the energy I need and the mental alertness to accomplish my goals on a daily basis. Also helps me accomplish my exercise goals.”
“I have been taking VitalFactors for several years now and I can say I definitely see and feel the difference! I follow the recommended usage of five days on/two days off and it is working great for me. I now have my wife on this product and highly recommend it to anyone who wants to feel (and look) their best.”
“I've been taking/drinking Vital Factors for at least 20 years and never want to stop. The benefits are amazing! Thank you for making such a great vitamin drink.”
“I tried out the Vital Factors to see if I could tell any difference in how I felt. I take several supplements already. After a week I could tell that I had more energy and stamina than I had been having which is one of the reasons I wanted to try it. I am now on auto-ship and looking to see if the things it says it will do actually do. But just being able to have the needed energy will keep me taking it.”
“Product easy to use, tablet dissolves easier now, and gives me more energy and focus just after a few days of starting it!”

“VitalFactors has been part of my routine for over 20 years. I wouldn't skip a week.”
Pat BooneSinger and film star, 20+ year customer

“I take VitalFactors and recommend it to my patients: an easy part of a healthy routine.”
Dr. Lisa LearnBoard Certified Plastic and Reconstructive Surgeon

“Fitness and nutrition go hand in hand. That's why I take VitalFactors as my favorite natural energizer.”
Chris CuomoTV journalist, NewsNation
Pat Boone, Dr. Lisa Learn and Chris Cuomo are compensated endorsers.
Drop two tablets into a glass of water, let them dissolve, and drink. Take it five days on and two days off. Most people take it Monday to Friday and skip the weekend.
VitalFactors has been designed around a weekly rhythm from the start. The cycle is what matters, not the exact days, and missing a day inside the week is fine.
Everyone is different. Many customers tell us they notice a difference within the first few weeks of taking it consistently. It is nutritional support, not a stimulant, so give it time.
No caffeine and no sugar. It is sweetened with monk fruit and stevia and has 24 calories per serving.
Yes. Pause, skip or cancel anytime from your MDR account. No phone call and no fees.
Every order is covered by our 90-day money-back guarantee. Call 1-800-637-8227 and we'll sort it out.
It contains soy. It does not contain dairy, gluten, yeast, eggs, fish, shellfish, tree nuts or peanuts.
If you take prescription medication, especially blood thinners, diabetes medication or hormone therapy, ask your doctor or pharmacist before starting VitalFactors.
MDR, an American nutrition company that has been making supplements since 1984.
Your next good habit
Start with free shipping and 90 days to decide.
Caution: Do not take this product if you have kidney, liver or gastrointestinal disease, or cancer. Consult your physician first if you are on a sodium- or potassium-restricted diet.
Allergy: Contains soy. Review the full Supplement Facts panel before use.
Pregnancy and nursing: Not intended for pregnant or nursing individuals. Consult a health care practitioner before using.
Medications: If you take prescription medication, especially blood thinners, diabetes medication or hormone therapy, ask your physician or pharmacist before using VitalFactors.
Storage: Keep in a cool, dry place away from direct sunlight and moisture. Do not refrigerate. Keep out of reach of children and pets.