Antioxidant defense
Resveratrol, EGCG, Grape Seed and Superoxide Dismutase help protect your cells against oxidative stress: daily wear and tear that contributes to aging.*
Feel young again.
VitalFactors® is a refreshing, sparkling drink with VitalNAD+™ and age-defying nutrients that support natural energy, mental clarity, muscle function, immune health and healthy aging, helping you stay sharp, active and full of vitality.*
Renews monthly. Cancel online anytime. Or buy once, $109
4.9 out of 5 customer rating
“…feeling great at 92, you can see why I call VitalFactors my Fountain of Youth!”
Pat Boone · Legendary Singer & Film Star · VitalFactors customer 
“Fitness and nutrition go hand in hand. That's why I take VitalFactors as my favorite natural energizer.”
Chris Cuomo · TV journalist, NewsNation · VitalFactors customer
4.9 / 5Customer rating
Since 1984Made by Medical Doctors Research
Free shippingOn every subscription
VitalFactors box and a glass of the drink
VitalFactors
4.9 out of 5 customer ratingA complete effervescent formula designed to support normal energy metabolism, antioxidant protection and healthy aging.
- VitalNAD+™NMN + NADH
- 0 gsugar
- 0 mgcaffeine
- 20*Servings
| Monthly | 3-Month | One-time | |
|---|---|---|---|
| Due today | $89 | $249 | $109 + $6.95 shipping |
| Price per box | $89 | $83 | $109 |
| Shipping | Free | Free | $6.95 |
| Free cream | No | Yes, $65 value | No |
| Renewal | Every month at $89 | Every 3 months at $249 | None, one delivery |
| Cancel online | Yes | Yes | Nothing to cancel |
Get 3 boxes for $249 and a free Anti-Aging Cream. Save $18 vs monthly.
Free shipping on subscriptions Pause, skip or cancel online
How to use
Drop two tablets into a glass of water, let them fully dissolve, and drink. Take VitalFactors five days on and two days off. One box: 40 tablets · 20 servings · a four-week supply.
What is inside
VitalNAD+™ (NMN and NADH), resVida® resveratrol, grape skin and seed extracts, EGCG from green tea and Extramel® S.O.D., plus vitamins, minerals, amino acids and CoQ10.
Shipping, returns & cancellation
Monthly and 3-Month Subscribe & Save ship free. Pause, skip or cancel a subscription online at any time. Every order is covered by a 90-day money-back guarantee.
The Science of Youthful Vitality.
An advanced nutritional approach to cellular energy, protection and renewal.
Stimulant-free energy support
VitalFactors® supports your body's natural energy production without caffeine or other stimulants.*
Repair & Renew
VitalFactors® provides key amino acids, vitamins and minerals your body needs to make proteins and support natural cell renewal, helping maintain healthy function throughout your brain and body.*
Who's it for?
VitalFactors® is for adults who want to support their energy, protect their cells, and stay active as they age. It combines our VitalNAD+™ Complex with antioxidants in a refreshing, sparkling drink that fits easily into your morning routine to support all-day stamina and robust health.*
Drop. Fizz. Sip.
Two tablets. One glass. Five days a week.
01Drop
Two tablets into a glass of water.
02Fizz
They dissolve completely and the water turns pink.
03Sip
Drink it five days a week, then take the weekend off.
Drop
Two tablets into a glass of water.
Fizz
They dissolve completely and the water turns pink.
Sip
Drink it five days a week, then take the weekend off.
The Powerful VitalFactors® Complex
VitalFactors goes beyond ordinary vitamins. Our formula is based on the latest research with the most effective nutrients: Youth Factors, Antioxidants, Amino Peptides, BioProtectors and Enzymes. These carefully selected compounds have been shown to nourish cells and support energy, renewal, muscle function and immune defenses, key foundations for staying healthy and strong as you age.*
VitalNAD+™
NMN + NADHNMN is a precursor your cells use to make NAD+, a coenzyme involved in normal energy metabolism.
Resveratrol
resVida® + grape skin and seedRed grape polyphenols that help support antioxidant protection.
EGCG
From green teaThe best-known green tea catechin, a plant antioxidant.
S.O.D.
Extramel® melon extractSuperoxide dismutase from cantaloupe, an antioxidant enzyme.
Also in every serving: vitamins A, C, D3, E and a full B complex, calcium, magnesium, selenium and potassium, plus L-glutamine, L-arginine, L-lysine, glycine and CoQ10.
What Is VitalNAD+™?
VitalNAD+™ is the combination of NMN and NADH in VitalFactors®, designed to support cellular energy.*
- Q. What is NAD, and why does my body need it?
NAD stands for nicotinamide adenine dinucleotide, a natural coenzyme, a helper molecule found in your cells. It exists in two forms, NAD+ and NADH, which your body continually converts from one to the other to help turn food into energy. NAD+ also supports enzymes involved in DNA repair and normal cell function.*
- Q. What is NMN?
NMN stands for nicotinamide mononucleotide. It is a building block your body uses to make NAD+. Human clinical studies have shown that NMN supplementation can increase NAD+ levels in the blood.
- Q. What is NADH?
NADH is the form of NAD that carries electrons used in energy production. It plays a role in your mitochondria, the energy-producing structures inside your cells, to help make ATP, the energy your cells use to function.
- Q. Why does VitalFactors include both?
They have complementary roles: NMN helps your body make NAD+, while NADH participates in producing ATP. We include both to support this essential energy system.*
- Q. What does cellular energy mean for my everyday life?
Your body needs energy every moment of every day. The energy processes involving NAD+ and NADH help:
- Power your heart as it pumps blood throughout your body.
- Fuel your brain as it processes information, learns and remembers.
- Keep your muscles working so you can move and stay active.
Supporting cellular energy helps your body perform the essential functions that keep you strong, focused and on the go with youthful vitality and good health.*
Your routine, delivered.
A fresh box arrives every month, so your five-days-on rhythm never runs dry. Change it whenever you like, online.
- $20 less than a single box
- Free shipping on every delivery
- Pause, skip or cancel online
Renews every month until you cancel.
Real customers. Real routines.
4.9Trusted for over 40 years
“I have taken VitalFactors and other MDR products religiously for over 30 years! When you think I topped the charts before Elvis, and I am still performing, feeling great at 92, you can see why I call VitalFactors my Fountain of Youth!”
“Fitness and nutrition go hand in hand. That's why I take VitalFactors as my favorite natural energizer.”
Nick Murtha, Catalyst Fitness Dr. Lisa Learn on VitalFactors (paid endorser) Dr. Lisa Learn is a paid MDR endorser. Individual results vary.
Dr. Russell Smith and Heather
My favorite drink
“Been taking VitalFactors for two months. Love the taste so much that it has become my favorite drink. Hate that I’m supposed to skip 2 days a week but I follow the regimen and am feeling amazing.”
I feel my best
“At age 76, I feel my absolute best when I take Vital Factors. It provides me the energy I need and the mental alertness to accomplish my goals on a daily basis. Also helps me accomplish my exercise goals.”
My wife takes it too
“I have been taking VitalFactors for several years now and I can say I definitely see and feel the difference! I follow the recommended usage of five days on/two days off and it is working great for me. I now have my wife on this product and highly recommend it to anyone who wants to feel (and look) their best.”
“I take VitalFactors and recommend it to my patients: an easy part of a healthy routine.”
Dr. Lisa LearnBoard Certified Plastic and Reconstructive Surgeon
Paid MDR endorser. Individual results vary.
How do I take VitalFactors?
Drop two tablets into a glass of water, let them dissolve, and drink. Take it five days on and two days off. Most people take it Monday to Friday and skip the weekend.
How many servings are in a box?
*1 serving = 2 EfferTabs. Each box has 40 EfferTabs (20 servings).
Why five days on and two days off?
VitalFactors has been designed around a weekly rhythm from the start. The cycle is what matters, not the exact days, and missing a day inside the week is fine.
How soon will I notice a difference?
Everyone is different. Many customers tell us they notice a difference within the first few weeks of taking it consistently. It is nutritional support, not a stimulant, so give it time.
Does it have caffeine or sugar?
No caffeine and no sugar. It is sweetened with monk fruit and stevia and has 24 calories per serving.
Can I cancel my subscription?
Yes. Pause, skip or cancel anytime from your MDR account. No phone call and no fees.
What if it isn't for me?
Every order is covered by our 90-day money-back guarantee. Call 1-800-637-8227 and we'll sort it out.
Does it contain allergens?
It contains soy. It does not contain dairy, gluten, yeast, eggs, fish, shellfish, tree nuts or peanuts.
Can I take it with my medications?
If you take prescription medication, especially blood thinners, diabetes medication or hormone therapy, ask your doctor or pharmacist before starting VitalFactors.
Who makes VitalFactors?
MDR, an American nutrition company that has been making supplements since 1984.
Two tablets away from your first glass.
Free shipping on every subscription. Pause, skip or cancel online.
Safety informationWarnings, allergens and storage
Caution: Do not take this product if you have kidney, liver or gastrointestinal disease, or cancer. Consult your physician first if you are on a sodium- or potassium-restricted diet.
Allergy: Contains soy. Review the full Supplement Facts panel before use.
Pregnancy and nursing: Not intended for pregnant or nursing individuals. Consult a health care practitioner before using.
Medications: If you take prescription medication, especially blood thinners, diabetes medication or hormone therapy, ask your physician or pharmacist before using VitalFactors.
Storage: Keep in a cool, dry place away from direct sunlight and moisture. Do not refrigerate. Keep out of reach of children and pets.