VitalFactors — Age-Defying Nutritional Complex
A bottle of dissolved VitalFactors beside the VitalFactors box on a marble counter.

Effervescent age-defying complex

The no-caffeine fizzy drink for steady energy and healthy aging.

Two tablets in a glass of water, five days on and two days off. No caffeine, no sugar, no crash.

With Super NAD⁺, Resveratrol, EGCG and S.O.D.

$89/month · cancel anytime · 90-day guarantee

4.8 average from verified customers

  • MDR · since 1984
  • 42 years of formulation
  • Doctor-formulated
  • cGMP compliant
  • 90-day guarantee

What's in the glass

Four actives the formula is built around, plus the everyday foundation.

VitalFactors is an age-defying nutritional complex built on Super NAD⁺, Resveratrol, EGCG and S.O.D., alongside vitamins, minerals, amino acids and plant antioxidants — in two effervescent tablets you drop into a glass of water, five days on and two days off.

Vitamins & minerals

The everyday foundation, each with its % Daily Value printed on the label.

Amino acids & peptides

A 3.52g cellular-support blend built into the formula, not bolted on.

Plant antioxidants

Super NAD⁺, Resveratrol, EGCG and S.O.D. — the four the box leads with.

VitalFactors box with effervescent tablet dissolving in glass

Age-defying nutritional complex

VitalFactors

4.8 · 40 verified reviews
$89/month

A no-caffeine fizzy drink for steady energy and healthy aging. Two effervescent tablets in a glass of water, five days on and two days off — with Super NAD⁺, Resveratrol, EGCG and S.O.D. alongside vitamins, minerals and amino acids.

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What your subscription includes

  • Free shipping, always
  • 90-day money-back guarantee
  • No hidden fees
  • Pause, skip, or cancel anytime

Benefits

  • Steady energy & stamina

    Built to support cellular energy and stamina for a clean lift through your day — no stimulants, no caffeine, no crash.

  • Antioxidant defense

    Resveratrol, EGCG, and S.O.D. help maintain your body's antioxidant defenses against the everyday oxidative stress behind how you feel and age.

  • Stimulant free

    No caffeine and no jitters, so it fits any time of day and works alongside your coffee instead of competing with it.

  • Built on a rhythm

    A 5-days-on, 2-days-off cycle designed to work with your body — a sparkling glass you reach for, not one more chore.

Adults focused on steady energy, antioxidant support and healthy aging, who would rather take their nutrition as a sparkling glass of water on a five-days-on, two-days-off rhythm.

A woman dropping a VitalFactors effervescent tablet into a glass of water.

Why people stay on it

Built to be easy to stay on.

Two tablets go into water and the formula is in solution before you drink it. Nothing to scoop, no chalky aftertaste — a glass people actually look forward to on their on-days.

  • Supports normal energy metabolism
  • Helps support antioxidant protection
  • Supports cellular wellness
  • Helps maintain immune system function
  • Designed for wellness and healthy-aging support
  • No caffeine, no sugar, no gluten

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

How VitalFactors works

One fizzy drink. The full complex, in solution.

VitalFactors is an age-defying nutritional complex — Super NAD⁺, Resveratrol, EGCG and S.O.D. alongside vitamins, minerals, amino acids and plant antioxidants — pressed into effervescent tablets. Drop two into a glass of water and the formula is in solution before you drink it.

  1. 01

    Drop two tablets into water

    Each effervescent tablet dissolves completely — vitamins, amino acids, antioxidants and plant compounds go straight into solution, ready to drink.

  2. 02

    Drink the fizzy glass on your on-days

    Tablets in solution absorb through the stomach lining within minutes, instead of waiting on digestion. It's how Europeans have taken micronutrients for decades — the way the body was designed to receive them.

  3. 03

    Five days on, two days off

    The 5-on / 2-off rhythm gives the body two recovery days each week, so it stays responsive to the actives instead of adapting around them. Most customers run Mon–Fri and skip the weekend.

Supplement Facts

Serving size 2 tablets · 20 servings per container

Amount per serving% Daily Value
  • Calories 24
  • Total Carbohydrates 0.48 g<1%†
  • Sodium 274 mg12%
  • Vitamin A (as Retinyl Palmitate) 30 mcg RAE2%
  • Vitamin C (as L-Ascorbic Acid) 100 mg111%
  • Vitamin D3 (as Cholecalciferol) 12.5 mcg (500 IU)63%
  • Vitamin E (as D-Alpha-Tocopherol Acetate) 10 mg67%
  • Vitamin B1 (from Thiamin Hydrochloride) 3 mg250%
  • Vitamin B2 (as Riboflavin) 3.4 mg262%
  • Niacinamide 24 mg150%
  • Vitamin B6 (from Pyridoxine) 6 mg353%
  • Folic Acid (from Pteroyl-L-Monoglutamic Acid) 200 mcg DFE50%
  • Vitamin B12 (from Methylcobalamin) 200 mcg8333%
  • Biotin 50 mcg167%
  • Pantothenic Acid 2 mg40%
  • Calcium (from Calcium Carbonate) 50 mg4%
  • Magnesium (from Trimagnesium Dicitrate) 60 mg14%
  • Selenium (from Selenomethionine) 20 mcg40%
  • Potassium 330 mg7%
Proprietary Blend3.52 g (3520 mg)
  • L-Glutamine
  • Arginine (as L-Arginine Hydrochloride)
  • Lysine (as L-Lysine Hydrochloride)
  • Nicotinamide Riboside Chloride (Super NAD+)
  • Glycine
  • Monk Fruit Extract (Momordica Grosvenovi, Fruit)
  • Grape Skin Extract (40% Resveratrol)
  • Co Enzyme Q10
  • Grape Seed Extract (Vitis Vinifera) (95% Proanthocyanidins)
  • Soy Isoflavones (contains Soy)
  • Green Tea Extract (EGCG - Epigallocatechin Gallate)
  • Laminaria Japonica Seaweed (80% Polysaccharides)
  • Resveratrol (from resVida®)
  • Lycopene
  • Superoxide Dismutase/Catalase (from Extramel® Melon)
  • Ornithine (as L-Ornithine Hydrochloride)
  • Lotus Seed Extract (Nelumbo Nucifera)

† Percent Daily Values are based on a 2,000 calorie diet.

* Daily Value not established.

resVida® is a U.S. & international registered trademark of DSM (Netherlands). Extramel® is a U.S. registered trademark of Bionov Corp. Lotus U.S. Patent # 5,925,348. Super NAD+ is a trademark of MDR Fitness Corp.

Other ingredients: citric acid, sodium bicarbonate, potassium bicarbonate, red fruit jelly flavor, berry flavor, steviol glycosides.

Contains: Soy.

View the printed label
42+
years of clinical formulation
20
servings per box
0
caffeine · 0 sugar · 0 gluten
90-day
money-back guarantee

Recommended by

Doctors, journalists, and artists who take it themselves.

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Customer testimonial
Customer testimonial
Dr. Smith on VitalFactors
  • Chris Cuomo

    Fitness and nutrition go hand in hand — that's why I take VitalFactors as my favorite natural energizer.

    Chris Cuomo

    TV journalist · NewsNation primetime

  • Dr. Lisa Learn

    I take VitalFactors and recommend it to my patients — an easy part of a healthy routine.

    Dr. Lisa Learn

    Board Certified Plastic & Reconstructive Surgeon

  • Pat Boone

    VitalFactors has been part of my routine for over 20 years — I wouldn't skip a week.

    Pat Boone

    Singer & film star · 20+ year user

Customer Reviews

What customers say.

4.7/ 5
★★★★★

Popular topics

★★★★★VerifiedVerified customer

Part of my routine for 20 years

I have been taking VitalFactors and other MDR vitamins for over 20 years. I topped the charts before Elvis, and I am still active and strong today — it's been part of my routine the whole way.

Pat Boone·Singer · Film star · 20+ year user
★★★★★VerifiedVerified customer

I recommend it to my patients

I take VitalFactors and recommend it to my patients — an easy part of a healthy routine.

Dr. Lisa Learn·Board Certified Plastic & Reconstructive Surgeon
★★★★★VerifiedJune 2024

Been taking VitalFactors for two months. Love the taste so much that it has become my favorite drink. Hate that I’m supposed to skip 2 days a week but I follow the regimen and am feeling amazing.

Kara K.
★★★★★VerifiedDecember 2022

At age 76, I feel my absolute best when I take Vital Factors. It provides me the energy I need and the mental alertness to accomplish my goals on a daily basis. Also helps me accomplish my exercise goals.

Judith H.
★★★★★VerifiedNovember 2022

THIS PRODUCT IS WAY BETTER THAN ALL MY EXPECTATIONS. IT IS MY FAVORITE SUPPLIMENT. I AM 71. THANK YOU

Jay M.

What's inside VitalFactors

Every ingredient, every dose, explained.

Vitamins, minerals, amino acids, antioxidants, and plant compounds — dissolved into a refreshing drink instead of swallowed as a handful of capsules. Tap any ingredient to see the amount on the label and why it's in the formula.

39ingredients2effervescent tablets per serving3.52gproprietary cellular-support blend

Free of: sugar, artificial dyes, cholesterol, lactose, gluten, yeast, dairy, eggs, fish, shellfish, tree nuts, peanuts, and animal ingredients. Naturally sweetened with monk fruit and stevia. Cruelty-free, vegan formula.

Allergen note: Contains soy isoflavones (a plant-based polyphenol).

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Ingredient descriptions reflect general structure-function support, not specific claims about VitalFactors or any individual outcome.

FAQ

Frequently asked.

Individual results vary. Many customers report feeling a difference in energy and focus within the first few weeks of consistent use on the 5-on / 2-off rhythm. Because VitalFactors works through nutritional support rather than a stimulant effect, most benefits build gradually with regular use.

Warnings & precautions

Caution: Do not take this product if you have kidney, liver, or gastrointestinal disease, or cancer. Consult your physician first if you are on a sodium- or potassium-restricted diet.

Allergy: Contains soy isoflavones. Free of gluten and artificial dyes. Review the full Supplement Facts panel before use.

Pregnancy & nursing: Not intended for pregnant or nursing individuals. Consult a health-care practitioner before using.

Drug interactions: If you take prescription medications, especially blood thinners, diabetes medications, or hormone therapies, ask your physician or pharmacist before using VitalFactors.

Storage: Cool, dry place, away from direct sunlight or moisture. Do not refrigerate. Keep out of reach of children or pets.

Caffeine: Contains none.